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課程名稱 |
高等化學生物學一
ADVANCED CHEMICAL BIOLOGY(I) |
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開課學期 |
97-1 |
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授課對象 |
理學院 化學所化學生物學組 |
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授課教師 |
方俊民 |
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課號 |
Chem7035 |
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課程識別碼 |
223 M1610 |
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班次 |
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學分 |
3 |
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全/半年 |
半年 |
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必/選修 |
必修 |
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上課時間 |
星期一6(13:20~14:10)星期三5,6(12:20~14:10) |
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上課地點 |
化217化217 |
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備註 |
本課程中文授課,使用英文教科書。限碩士生修習。與陳振中、林俊宏合開
總人數上限：50人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/971961AdvChemBiol_1 |
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課程簡介影片 |
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核心能力關聯 |
本課程尚未建立核心能力關連 |
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課程大綱
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為確保您我的權利,請尊重智慧財產權及不得非法影印
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課程概述 |
Structural Determination and Sequencing of Biomolecules
1. Overview of Chemical Biology
2. Struct. Determ. of Small Molecules
3. Struct. Determ. & Sequencing of Proteins
4. Struct. Determ. & Sequencing of Nucleic Acids
5. Struct. Determ. & Sequencing of Carbohydrates
Protein Dynamics
1. Protein Folding and Misfolding
2. Biological Membranes
3. Membrane Proteins
Enzyme Mechanism and Functionc
1. Enzymes as wonderful catalysts and models for studying enzymatic reactions
2. Hydrolytic enzyme and enzymetic redoc chemistry
3. Enzymetic C-C bound formation and enzymatic addition and elimination
4. Enzymatic transformations of amino acids and isomerases
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課程目標 |
The students in this course will be grouped into several teams. In principle, a team will consist of 3–6 students from different disciplines to work together. Each team will be assigned a small project to finish before oral presentation; that is, each team must submit a written report (3 hard copies) and a powerpoint electronic file for oral presentation to Professor Fang by December 8. The written report must include description of each slide presented in the powerpoint file. All these materials will be posted on the course website. Only one student in each team will be drawn on site as the team representative to give oral presentation. |
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課程要求 |
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預期每週課後學習時數 |
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Office Hours |
另約時間 |
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指定閱讀 |
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參考書目 |
1.Chemical Biology: from Small Molecules to System Biology and Drug Design, 3
volumes, Wiley-VCH: Weinheim, 2007
2.Comprehensive Glycoscience: from Chemistry to Systems Biology, 4 volumes,
Elsevier: Oxford, 2007
3.An Introduction to Practical Biochemistry, 3rd ed., McGraw-Hill Book
Company: Maidenhead, England, 1987
4.Principles and Techniques of Practical Biochemistry, 5th ed., Cambridge
University Press: Cambridge, UK, 2000
5.Bioanalytical Chemistry, Wiley: Hoboken, New Jersey, USA, 2004
6.Analytical Techniques in DNA Sequencing, Taylor & Francis: Boca Raton, FL,
USA, 2005
7.Separation Methods in Proteomics, Taylor & Francis: Boca Raton, FL, USA, 2006
8.One-Dimensional and Two-Dimensional NMR Spectra by Modern Pulse Techniques,
Kodansha, Tokyo, Japan, 1990
9.The Organic Chemistry of Biological Pathways, Roberts and Co. Publishers:
Englewood, Colorado, 2005
10.Evaluation of Enzyme Inhibitors in Drug Discovery; Wiley: 2005 |
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評量方式
(僅供參考) |
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No. |
項目 |
百分比 |
說明 |
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1. |
期中考 |
35% |
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2. |
期末考 |
50% |
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3. |
隨堂測驗 |
0% |
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4. |
作業 |
0% |
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5. |
報告 |
15% |
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週次 |
日期 |
單元主題 |
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第1週 |
9/15, 9/17 |
Overview of Chemical Biology |
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第2週 |
9/22, 9/24 |
Struct. Determ. of Small Molecules |
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第3週 |
9/22, 9/24 |
Struct. Determ. |
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第4週 |
10/6, 10/8 |
Struct. Determ. |
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第5週 |
10/13, 10/15 |
Struct. Determ. |
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第6週 |
10/20, 10/22 |
Protein Folding and Misfolding |
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第7週 |
10/29 |
Protein Folding and Misfolding |
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第8週 |
11/3, 11/5 |
Biological Membranes |
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第9週 |
11/10, 11/12 |
Membrane Proteins |
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第10週 |
11/17 |
Second Examination |
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第11週 |
11/24, 11/26 |
Hydrolytic enzymes and enzymatic redoc chemistry |
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第12週 |
12/1, 12/3 |
Enzymatic C–C bond formation and enzymatic addition and elimination |
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第13週 |
12/8, 12/10 |
Enzymatic transformations of amino acids and isomerases |
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第14週 |
12/15, 12/17 |
Students’ Oral Presentation |
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第15週 |
12/22, 12/24 |
Students’ Oral Presentation |
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第16週 |
12/29, 12/31 |
Special Topics in Bioorganic Chemistry |
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第17週 |
1/5, 1/7 |
Special Topics in Bioorganic Chemistry |
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第18週 |
1/12 |
Final Exam |
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第7-1週 |
10/27 |
First Examination |
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第10-1週 |
11/19 |
Enzymes as wonderful catalysts and models for studying enzymatic reactions |
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